Amphiphilic Fullerene‐BODIPY Photosensitizers for Targeted Photodynamic Therapy

• DOI: 10.1002/cmdc.202100693
• Publication Date: 2021-12-03T03:12:22Z
• Authors: Ezel Öztürk Gündüz; M. Emre Gedik; Gürcan Günaydın; Elif Okutan
• Keywords: BODIPY; Phototoxicity; Corrole

Nanotheranostic tailor-made carriers are potent platforms for the treatment of cancer that propound a number advantages over conventional agents photodynamic therapy (PDT). Herein, four new heavy atom free amphiphilic glucose-BODIPY-fullerene dyads (14-17) endowed with carbohydrate units in styryl units, which can also form nanomicelles (14-17NM) Tween 80 PDT reported. Glucose-BODIPY-fullerene systems and related have been prepared to emcee efficient singlet oxygen generation upon light irradiation. In vitro anti-tumor effects compounds 14-17 14-17NM presence darkness investigated K562 human chronic myelogenous leukemia suspension cells. Anti-tumor toxicity irradiation was due formation reactive species (ROS). This study may provide an accomplished example applications based on nanovehicles fabricated universal spin converter, fullerene, harvesting unit, BODIPY dyes conjugated targeting fight against cancer.