Effects of Structural Variations on Antibacterial Properties for Conjugated Diynes Generated through Glaser Hay Couplings

• DOI: 10.1002/cmdc.202200455
• Publication Date: 2022-10-04T16:33:19Z
• Authors: Emma A. Hale; Hannah M. Ryan; Alexandra M. McOsker; Cody M. Funk; Lauren C. Green; Lauren E. Mazur; Diya M. Uthappa; Brian M. Flood; Douglas D. Young; Robert J. Hinkle
• Keywords: Natural product

Antibiotic resistance is a growing problem facing global societies today. Many new antibiotics are derivatized versions of already existing antibiotics, which allows for antibiotic to arise. To combat this issue, with different core structures need be elucidated. Asymmetrical polyacetylenes have been isolated from natural products and they previously demonstrated exhibit antimicrobial antibacterial activity; however, their synthetic preparation has not made them easily amenable rapid derivatization SAR studies. Using combination solution solid-supported chemistries, an array diynes inspired by known product were prepared assessed activity. Ultimately, several compounds identified improved activity in bacterial viability assays. Moreover, some discovered that displayed degree specificity E. coli over P. fluorescens vice versa. These show promise, further investigation needed pinpoint the specific structural components elicit biological