5‐Substituted Uridines with Activity against Gram‐Positive Bacteria
Mycobacterium smegmatis
Ribonucleoside
Gram-Positive Bacteria
DOI:
10.1002/cmdc.202300366
Publication Date:
2023-09-14T17:45:30Z
AUTHORS (14)
ABSTRACT
The emergence of drug-resistant strains pathogenic microorganisms necessitates the creation new drugs. A series uridine derivatives containing an extended substituent at C-5 position as well alkyloxymethyl, alkylthiomethyl, alkyltriazolylmethyl, alkylsulfinylmethyl and alkylsulfonylmethyl uridines were obtained in order to explore their antimicrobial properties solubility. It has been shown that ribonucleoside have magnitude better solubility water compared 2'-deoxy analogues effectively inhibit growth a number Gram-positive bacteria, including resistant Mycobacterium smegmatis (MIC=15-200 μg/mL) Staphylococcus aureus (MIC=25-100 μg/mL). Their activity is comparable some antibiotics used medicine.
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