5‐Substituted Uridines with Activity against Gram‐Positive Bacteria

• DOI: 10.1002/cmdc.202300366
• Publication Date: 2023-09-14T17:45:30Z
• Authors: Dmitry A. Makarov; Sergey D. Negrya; Maxim V. Jasko; Inna L. Karpenko; Pavel N. Solyev; Vladimir O. Chekhov; Dmitry N. Kaluzhny; Olga V. Efremenkova; Byazilya F. Vasil...; Alexander O. Chizhov; Darya A. Avdanina; Alexander A. Zhgun; Sergey N. Kochetkov; Liudmila A. Alexa...
• Keywords: Mycobacterium smegmatis; Ribonucleoside; Gram-Positive Bacteria

The emergence of drug-resistant strains pathogenic microorganisms necessitates the creation new drugs. A series uridine derivatives containing an extended substituent at C-5 position as well alkyloxymethyl, alkylthiomethyl, alkyltriazolylmethyl, alkylsulfinylmethyl and alkylsulfonylmethyl uridines were obtained in order to explore their antimicrobial properties solubility. It has been shown that ribonucleoside have magnitude better solubility water compared 2'-deoxy analogues effectively inhibit growth a number Gram-positive bacteria, including resistant Mycobacterium smegmatis (MIC=15-200 μg/mL) Staphylococcus aureus (MIC=25-100 μg/mL). Their activity is comparable some antibiotics used medicine.