Copper and Copper Complexes in Tumor Therapy

• DOI: 10.1002/cmdc.202400060
• Publication Date: 2024-03-06T04:04:42Z
• Authors: Yingqiao Wang; Tingxi Tang; Yi Yuan; Nan Li; Xiaoqing Wang; Jian Guan
• Keywords: 0301 basic medicine; 03 medical and health sciences; Molecular Structure; Coordination Complexes; Neoplasms; Humans; Animals; Antineoplastic Agents; Copper; Chelating Agents

AbstractCopper (Cu), a crucial trace element in physiological processes, has garnered significant interest for its involvement in cancer progression and potential therapeutic applications. The regulation of cellular copper levels is essential for maintaining copper homeostasis, as imbalances can lead to toxicity and cell death. The development of drugs that target copper homeostasis has emerged as a promising strategy for anticancer treatment, with a particular focus on copper chelators, copper ionophores, and novel copper complexes. Recent research has also investigated the potential of copper complexes in cancer therapy.