Predictive clinical outcome of the intratumoral CD66b‐positive neutrophil‐to‐CD8‐positive T‐cell ratio in patients with resectable nonsmall cell lung cancer

• DOI: 10.1002/cncr.26456
• Publication Date: 2011-09-01T02:34:41Z
• Authors: Marius Ilie; Véronique Hofman; Cécile Ortholan; Christelle Bonnetaud; Céline Coëlle; Jérôme Mouroux; Paul Hofman
• Keywords: Univariate analysis; Cluster of differentiation; Carcinoembryonic antigen

Abstract BACKGROUND: The role of the interaction between tumor cells and inflammatory in nonsmall cell lung carcinoma (NSCLC) is unclear. In this study, authors assessed prognostic impact intratumoral cluster differentiation 66b (carcinoembryonic antigen‐related adhesion molecule 8 [CD66b])‐positive neutrophils CD66b‐positive neutrophil‐to‐cluster (cell surface antigen T8 [CD8])‐positive lymphocytes (the neutrophil‐to‐CD8‐positive lymphocyte ratio [iNTR]) patients with resectable NSCLC. METHODS: Expression levels CD66b CD8 were evaluated by immunohistochemistry on tissue microarrays consisting 632 NSCLC specimens from who underwent curative surgery. relation clinicopathologic variables patient outcome was assessed. RESULTS: Intratumoral elevated 318 (50%). univariate analysis, an increase associated a high cumulative incidence relapse (CIR) (median CIR, 51 months for low density; 36 P = .002) trended toward worse overall survival (OS) OS, 57 54 .088). iNTR 190 (30%). An increased strongly both CIR CIR: 43 ≤1; 34 >1; < .0001) poor OS OS: 60 46 .0001). multivariate independent factors higher (hazard [HR], 0.71; 95% confidence interval [CI], 0.56‐0.90; .005) stage >I, (HR, 0.39; CI, 0.30‐0.52; Independent 0.70; 0.54‐0.91; .007) >I 0.35; 0.26‐0.47; CONCLUSIONS: current results indicated that novel, factor rate disease recurrence Cancer 2011;. © 2011 American Society.