Mutant IDH1 inhibits PI3K/Akt signaling in human glioma

• DOI: 10.1002/cncr.28732
• Publication Date: 2014-04-25T19:09:16Z
• Authors: Peter Birner; Stefan Pusch; Christo Christov; Stiliana Mihaylova; Kalina Toumangelo...; Sevdalin Natchev; Sebastian F. Scho...; Andrey Tchorbanov; Berthold Streubel; Jochen Tuettenberg; Marin Guentchev
• Keywords: Isocitrate dehydrogenase

BACKGROUND Recently, isocitrate dehydrogenase 1 ( IDH1 ) was identified as a major participant in glioma pathogenesis. At present, the enzymatic activity of protein has been main topic investigating its physiological function, but signaling pathway allocation unsuccessful. Interestingly, proteins regulated by phosphoinositide 3‐kinase (PI3K)/Akt signaling, are among top downregulated genes gliomas associated with high percentage and IDH2 mutations. The aim this study to investigate hypothetical relation between PI3K signaling. METHODS presence mutant markers for active PI3K/Akt present phosphorylated Akt podoplanin (PDPN), were investigated discovery cohort 354 patients glioma. In vitro experiments used confirm functional links. RESULTS This shows an inverse correlation support link these molecules, expression inhibited phosphorylation 2‐hydroxyglutarate–dependent manner. CONCLUSIONS provides patient tumor evidence suggesting that inhibits Cancer 2014;120:2440–2447 . © 2014 American Society