Associations of breast cancer related exposures and gene expression profiles in normal breast tissue—The Norwegian Women and Cancer normal breast tissue study

• DOI: 10.1002/cnr2.1777
• Publication Date: 2023-01-09T06:15:30Z
• Authors: Sanda Krum‐Hansen; Karina Standahl O...; Endre Anderssen; Jan Ole Frantzen; Eiliv Lund; Ruth H. Paulssen
• Keywords: Breast tissue

Abstract Background Normal breast tissue is utilized in tissue‐based studies of carcinogenesis. While gene expression tumor well explored, our knowledge transcriptomic signatures normal still incomplete. The aim this study was to investigate variability a large sample biopsies, according cancer related exposures (obesity, smoking, alcohol, hormone therapy, and parity). Methods We analyzed profiles from 311 biopsies cancer‐free, post‐menopausal women, using Illumina bead chip arrays. Principal component analysis K ‐means clustering used for initial the dataset. association covariates with determined linear models microarrays. Results Heterogeneity cell composition had strongest influence on profiles. After adjusting composition, obesity, alcohol showed highest numbers associated genes pathways, whereas therapy parity were negligible differences. Conclusion Our results provide insight into associations between major an informative baseline improved understanding exposure‐related molecular events women.