Guanidinium Group Remains Protonated in a Strongly Basic Arginine Solution

• DOI: 10.1002/cphc.201700197
• Publication Date: 2017-02-23T20:27:23Z
• Authors: Bo Xu; Michael I. Jacobs; Oleg Kostko; Musahid Ahmed
• Keywords: Dissociation constant; Acid dissociation constant

Knowledge of the acid dissociation constant an amino has very important ramifications in biochemistry proteins and lipid bilayers aqueous environments because charge proton transfer depend on its value. The for guanidinium group arginine historically been posited as 12.5, but there is substantial variation published values over years. Recent experiments suggest that much higher than which explains why retains positive under all physiological conditions. In this work, we use X-ray photoelectron spectroscopy to study unsupported, nanoparticles. By varying pH constituent solution, provide evidence protonated even a basic solution. analyzing energy shifts C N spectra, establish molecular level picture how transport solutions occur.