Non‐Pairwise Interactions in Parahydrogen Experiments: Nuclear Exchange of Single Protons Enables Bulk Water Hyperpolarization

• DOI: 10.1002/cphc.201800521
• Publication Date: 2018-07-30T15:19:12Z
• Authors: Meike Emondts; Daniel Schikowski; Jürgen Klankermayer; P. Philipp M. Sch...
• Keywords: Hyperpolarization; Induced polarization

Hyperpolarization with parahydrogen (p-H2 ) is a fast developing field in NMR, which enables overcoming the inherent low sensitivity of this important technique. The hyperpolarization solvents, particularly water, offers wide range applications for structural investigations macromolecules and biomedical imaging. Until lately, only organic solvents could be polarized by means via coherent redistribution polarization (SABRE mechanism). In study, we investigate detail mechanism recently reported bulk water combination theoretical experimental methods, finally showing chemical exchange pathway single protons as basis enhancement. prerequisites preserving upon separation two hydrogen atoms p-H2 are demonstrated examinations boundary conditions experiments accordance OneH-PHIP theory. These findings yielded proposal novel NEPTUN (Nuclear Exchange Polarization Transposing Unattached Nuclei) non-hydrogenative equivalent to established thus missing link