State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions

• DOI: 10.1002/cphy.c200033
• Publication Date: 2022-03-09T12:29:50Z
• Authors: Kaleen M. Lavin; Paul M. Coen; Liliana C. Baptista; Margaret B. Bell; Devin Drummer; Sara A. Harper; Manoel E. Lixandrão; Jeremy S. McAdam; Samia M. O'Bryan; Sofhia Ramos; Lisa M. Roberts; Rick B. Vega; Bret H. Goodpaster; Marcas M. Bamman; Thomas W. Buford

For centuries, regular exercise has been acknowledged as a potent stimulus to promote, maintain, and restore healthy functioning of nearly every physiological system the human body. With advancing understanding complexity physiology, continually evolving methodological possibilities, an increasingly dire public health situation, study preventative or therapeutic treatment never more interdisciplinary, impactful. During early stages NIH Common Fund Molecular Transducers Physical Activity Consortium (MoTrPAC) Initiative, field is well-positioned build substantially upon existing mechanisms underlying benefits associated with exercise. Thus, we present comprehensive body knowledge detailing current literature basis surrounding molecular adaptations in humans provide view state at this critical juncture, well resource for scientists bringing external expertise physiology. In reviewing related cellular processes exercise-induced adaptations, also draw attention gaps warranting continued research effort. © 2021 American Physiological Society. Compr Physiol 12:3193-3279, 2022.