Evaluation of Maternal Drug Exposure Following the Administration of Antenatal Corticosteroids During Late Pregnancy Using Physiologically‐Based Pharmacokinetic Modeling

• DOI: 10.1002/cpt.1438
• Publication Date: 2019-03-29T16:15:06Z
• Authors: Alice Ban Ke; Mark A. Milad
• Keywords: Drugs in pregnancy; Drug Administration

Betamethasone and dexamethasone are the most widely studied antenatal corticosteroids ( ACS ) administered to pregnant women, just prior birth of a preterm neonate, accelerate fetal lung maturation. Although betamethasone, predominantly used in developed countries, has been shown be an effective safe intervention for reducing neonatal mortality, choice optimal dosing low middle income countries LMIC s) remains unclear. This is primarily because exposure–response relationships have not established despite long history use. As first step toward use s, we physiologically‐based pharmacokinetic (PBPK) models describe kinetics following i.v., p.o., or i.m. dosing. In vitro data describing cytochrome P450 3A4 enzyme contribution were incorporated this was refined using clinical data. The can applied prospectively predict women receiving various regimens.