Process Development of Heterogeneous Rh Catalyzed Carbene Transfer Reactions Under Continuous Flow Conditions

• DOI: 10.1002/cssc.202300596
• Publication Date: 2023-05-15T13:50:11Z
• Authors: Tahani A. C. A. B...; Camille Lescot
• Keywords: Flow chemistry

A very simple Rh-based catalyst operates under heterogeneous flow conditions for the carbene transfer of methyl diazoacetate (MDA) with several substrates. Two different methods heterogenizing in a column reactor have been applied. Different X-H (X=O, S, Si, CH2 ) were successfully functionalized by and cyclopropenation was performed mild continuous conditions. Following these promising results, recycling experiments using both methodologies conducted which up to 5 catalytic cycles achieved O-H insertion reaction interestingly, sequential transformation substrates 10 consecutive runs per no loss activity, thus allowing production families compounds.