Exploring the links among peripheral immunity, biomarkers, cognition, and neuroimaging in Alzheimer's disease

• DOI: 10.1002/dad2.12517
• Publication Date: 2023-12-20T04:45:38Z
• Authors: Jie‐Qiong Li; Ya‐Ru Zhang; Hui‐Fu Wang; Yu Guo; Xue‐Ning Shen; Meng‐Meng Li; Jing‐Hui Song; Lan Tan; An‐Mu Xie; Jin‐Tai Yu
• Keywords: Cognitive Decline

Abstract INTRODUCTION We analyzed relationships among peripheral immunity markers, cognition, Alzheimer's disease (AD)‐related biomarkers, and neuroimaging to understand involvement in AD. METHODS Peripheral markers were assessed AD, non‐AD neurodegenerative disorders, controls, examining their connections with AD‐related using multiple regression models. RESULTS The study included 1579 participants. Higher levels of white blood cell, neutrophil, monocyte, neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte (PLR), systemic immune‐inflammation index (SII), lower lymphocyte‐to‐monocyte (LMR) associated cognitive decline more severe anxiety depression. impact LMR, lymphocyte count, higher NLR on is mediated through cerebrospinal fluid amyloid beta (Aβ) levels. Additionally, increased PLR, NLR, SII brain atrophy hippocampal Aβ deposition (amyloid positron emission tomography). DISCUSSION offer a non‐invasive cost‐effective means studying pathophysiological changes, providing valuable insights into its pathogenesis treatment. Highlights linked anxiety/depression. Low LYM, high reduced CSF Aβ, impacting cognition. High