Delayed primacy recall performance predicts post mortem Alzheimer's disease pathology from unimpaired ante mortem cognitive baseline

• DOI: 10.1002/dad2.12524
• Publication Date: 2024-01-18T12:40:05Z
• Authors: Davide Bruno; Kristina M. Gicas; Ainara Jauregi‐Zi...; Kimberly D. Mueller; Melissa Lamar
• Keywords: Neuropathology

Abstract We propose a novel method to assess delayed primacy in the Consortium Establish Registry for Alzheimer's Disease (CERAD) memory test. then examine whether this measure predicts post mortem disease (AD) neuropathology individuals who were clinically unimpaired at baseline. A total of 1096 selected from Rush Center database registry. All participants baseline, and had subsequently undergone brain autopsy. Average age baseline was 78.8 (6.92). Bayesian regression analysis carried out with global pathology as an outcome; demographic, clinical, apolipoprotein E ( APOE) data covariates; cognitive predictors, including primacy. Global AD best predicted by Secondary analyses showed that mostly associated neuritic plaques, whereas recall neurofibrillary tangles. Sex differential associations observed. conclude CERAD‐derived is useful metric early detection diagnosis individuals. Highlights analyse serial position CERAD cognitively Delayed better than traditional metrics.