The meaning of high‐risk HPV other than type 16/18 in women with negative cytology: Is it really safe to wait for 1 year?

• DOI: 10.1002/dc.24705
• Publication Date: 2021-02-06T03:18:52Z
• Authors: Canan Kabaca; Burak Giray; Mine Guray Uzun; Serkan Akis; Yunus Emre Purut; Esra Keles Peker; Handan Cetiner; Evrim Bostanci Ergen
• Keywords: Adult; 03 medical and health sciences; 0302 clinical medicine; Colposcopy; Papillomavirus Infections; Humans; Uterine Cervical Neoplasms; Female; Middle Aged; Uterine Cervical Dysplasia; Human Papillomavirus DNA Tests; Papanicolaou Test; 3. Good health

AbstractBackgroundHuman papillomavirus (HPV) is a primary risk factor for cervical cancer. HPV 16 and 18 are the two most carcinogenic genotypes and have been reported in the majority of cervical cancer. High‐risk HPVs (hrHPVs) other than HPV 16/18 cause approximately a quarter of cervical cancers. We aimed to present the colposcopy‐guided biopsy results of non‐16/18 hrHPV‐infected women with negative cytology.MethodsThis is a retrospective cohort study conducted on 752 patients between the ages of 30‐65 years with non‐16/18 hrHPV and negative cytology undergoing colposcopy‐guided biopsy at a tertiary gynecological cancer center between January‐2016 and January‐2019.ResultsThe mean age of the women was 42.35±9.41 years. Cervical intraepithelial neoplasia (CIN) 2+ lesion was detected in 49 (6.5%) women with negative cytology. The rate of CIN 2+ lesions in women with abnormal cytology was 12.8%. Patients with abnormal cytology had about 2.1 and 2.4 times increased the odds of CIN 2+ lesion in cervical biopsy and endocervical curettage specimens, respectively. CIN 3+ lesion was detected in 20 (2.7%) women with negative cytology. One (0.1%) of the patients with HPV 39 and negative cytology had invasive cervical cancer. The two most common HPV subtypes were HPV 31 and HPV 51.ConclusionsThe risk of cervical preinvasive lesions still can be detected and cannot be completely eliminated among hrHPV other than 16/18‐infected women with negative cytology. Based on the results of this study, referral of non‐16/18 hrHPV‐infected women with negative cytology to colposcopy is supported as a credible and feasible strategy.