Structure and modeling in the design of β‐ and γ‐secretase inhibitors

• DOI: 10.1002/ddr.20291
• Publication Date: 2009-02-27T16:25:07Z
• Authors: M. Katharine Holl...; Peter Hunt; Georgia B. McGaughey
• Keywords: Molecular model

Abstract This review discusses the involvement of structure and modeling in design β‐secretase (BACE‐1) γ‐secretase inhibitors as putative Alzheimer's Disease therapeutics. The early broad availability structural information for BACE‐1, a membrane‐tethered aspartyl protease, has led to use silico methods overall optimization process. However, γ‐secretase, an integral membrane protein, lack detailed 3D limited application computational methods. Drug Dev Res 70, 2009. © 2009 Wiley‐Liss, Inc.