Feasibility and safety of 0.6% sodium alginate in endoscopic submucosal dissection for colorectal neoplastic lesion: A pilot study

• DOI: 10.1002/deo2.313
• Publication Date: 2023-11-04T08:26:20Z
• Authors: Hajime Nakamura; Rie Morita; Ryo Ito; Akira Sakurada; Natsumi Tomita; Yuya Hirata; Yusuke Kanari; Yuya Komatsu; Kunihiro Takanashi; Tomonori Anbo; Shinichi Katsuki
• Keywords: Endoscopic submucosal dissection; Perforation; Clinical endpoint; Endoscopic mucosal resection

The usefulness of 0.6% sodium alginate (SA) as a submucosal (SM) injection solution for endoscopic SM dissection (ESD) has gained attention over the past few years. However, using ESD colorectal neoplastic lesions is not explicitly researched yet. Thus, we conducted this study to determine feasibility and safety SA ESD.In single-center, retrospective pilot study, total 100 cases treated with neoplasia at our institute were retrospectively reviewed clarify clinical SA. primary endpoint was evaluate complication rate, secondary procedure time amount used.Intraoperative perforation observed in 1 case (1.0%), 2 (2.0%) presented postprocedural hemorrhage, no lethal adverse events observed. median times 39.5 min (10-150), used less than 20 mL 67 (67.0%). En-bloc resection could be achieved 97 (97.0%). Although six underwent subsequent surgery due deep invasion (>1000 μm), there nodal involvement, confirmed through histopathological evaluation.Our findings indicate that can potentially ensure safe secure neoplasia.