Lessons learned from the 1‐hour post‐load glucose level during OGTT: Current screening recommendations for dysglycaemia should be revised

• DOI: 10.1002/dmrr.2992
• Publication Date: 2018-02-21T18:35:54Z
• Authors: Michael Bergman; Ram Jagannathan; Martin Buysschaert; Manan Pareek; Michael H. Olsen; Peter M. Nilsson; José Luis Medina; Jesse Roth; Angela Chetrit; Leif Groop; Rachel Dankner
• Keywords: Prediabetes; Blood sugar regulation

Abstract This perspective covers a novel area of research describing the inadequacies current approaches for diagnosing dysglycaemia and proposes that 1‐hour post‐load glucose level during 75‐g oral tolerance test may serve as biomarker to detect earlier than currently recommended screening criteria disorders. Considerable evidence suggests plasma value ≥155 mg/dl (8.6 mmol/L) identify individuals with reduced β‐cell function prior progressing prediabetes diabetes is highly predictive those likely progress more HbA 1c or 2‐hour values. An elevated was better predictor type 2 isolated levels in Indian, Japanese, Israeli Nordic populations. Furthermore, epidemiological studies have shown PG predicted progression well increased risk microvascular disease mortality when <140 (7.8 mmol/L). The myocardial infarction fatal ischemic heart also greater among subjects were risks retinopathy peripheral vascular complications Swedish cohort. authors believe considerable base supports redefining diagnostic recommendations level. Measurement would increase likelihood identifying larger, high‐risk group additional practical advantage potentially replacing conventional making it acceptable clinical setting.