Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese elderly diabetes intervention trial (J‐EDIT)

• DOI: 10.1002/dmrr.632
• Publication Date: 2006-02-28T11:49:08Z
• Authors: Taichi Akisaki; Takashi Sakurai; Toshihiro Takata; Hiroyuki Umegaki; Atsushi Araki; Sachiko Mizuno; Shiro Tanaka; Yasuo Ohashi; Akihisa Iguchi; Koichi Yokono; Hideki Ito
• Keywords: Cognitive Decline; Stroop effect

Abstract Background Type 2 diabetes is associated with cognitive dysfunction and increases the risk of dementia in elderly. The aim this study was to explore, by means magnetic resonance (MR) imaging, possible relationships among clinical profiles diabetes, function, white matter hyperintensities (WMHs) subcortical brain atrophy. Methods Data were obtained from 95 nondemented type diabetic participants aged 65 years or over, enrolled an intervention trial for Japanese elderly patients. Cognitive function measured neuropsychiatric tests, including mini‐mental state examination (MMSE), verbal memory, digit symbol substitution Stroop tests. Hyperintensity classified into periventricular, deep matter, thalamic basal ganglia. Four ventricle‐to‐brain ratios used measure To identify features indices glycemic control, lipid metabolism, blood pressure complications examined. Canonical correlation analysis regression assess correlation. Results Scores MMSE negatively correlated WMHs parietal lobe thalamus, respectively. Lower scores memory showed positive association enlarged atrophy adjacent lateral ventricles. There no between pictures patients those morphological changes brain. Conclusions Impaired domains speed mental processes Degenerative cerebral small vessels may constitute predictive factors rate Copyright © 2006 John Wiley & Sons, Ltd.