Aortic thoracic neuromodulation in heart failure with preserved ejection fraction

• DOI: 10.1002/ehf2.14136
• Publication Date: 2022-09-24T07:44:18Z
• Authors: Pasquale Paolisso; Amir Dagan; Emanuele Gallinoro; Cristina De Colle; Dario Tino Bertolone; Ana Moya; Martin Penicka; Ivan Degrieck; Marc Vanderheyden; Jozef Bartunek
• Keywords: Neuromodulation

Abstract The inadequacy of medical therapies for heart failure with preserved ejection fraction (HFpEF) is driving the development device‐based solutions targeting underlying pathophysiologic abnormalities. maladaptive autonomic imbalance a reduction in vagal parasympathetic activity and increased sympathetic signalling contributes to deterioration cardiac performance, patient fitness, overall morbidity mortality. Thoracic aortic afferents mediate signalling, their stimulation has been postulated restore balance. In this first‐in‐man experience chronic (Harmony™ System, Enopace, Israel), we demonstrate improved left atrial remodelling function parallel ventricular performance. observed favourable structural functional changes remained stable throughout 1 year follow‐up were associated symptoms physical fitness. current warrants further validation endovascular thoracic as new interventional approach treatment HFpEF.