Sex differences in long‐term outcomes following acute heart failure hospitalization: Findings from the Get With The Guidelines‐Heart Failure registry

• DOI: 10.1002/ejhf.3003
• Publication Date: 2023-08-26T10:15:31Z
• Authors: Neil Keshvani; Sonia Shah; Iyanuoluwa Ayodele; Karen Chiswell; Brooke Alhanti; Larry A. Allen; Stephen J. Greene; Clyde W. Yancy; Windy W. Alonso; Harriette GC Van ...; Gregg C. Fonarow; Paul A. Heidenreich; Ambarish Pandey
• Keywords: Male; Aged, 80 and over; Heart Failure; Ejection fraction; Sex Characteristics; Aftercare; Heart failure; Stroke Volume; Outcomes; Prognosis; Medicare; United States; Patient Discharge; 3. Good health; Hospitalization; Sex differences; 80 and over; Humans; Female; Registries; Aged

Abstract Aims Sex differences in long‐term outcomes following hospitalization for heart failure (HF) across ejection fraction (EF) subtypes are not well described. In this study, we evaluated the risk of mortality and rehospitalization among males females spectrum EF over 5 years follow‐up an index HF event. Methods results Patients hospitalized with between 1 January 2006 31 December 2014 from American Heart Association's Get With The Guidelines‐Heart Failure registry available 5‐year using Medicare Part A claims data were included. association sex readmission a period each subtype (HF reduced [HFrEF, ≤40%], mildly [HFmrEF, 41–49%], preserved [HFpEF, >50%]) was assessed adjusted Cox models. effect modification by including multiplicative interaction terms total 155 670 patients (median age: 81 years, 53.4% female) Over follow‐up, had comparably poor survival post‐discharge; however, (vs. males) greater lost to compared median age‐ sex‐matched US population (HFpEF: 17.0 vs. 14.6 years; HFrEF: 17.3 15.1 HFmrEF: 17.7 age group 65‐69 years). analysis, lower (adjusted hazard ratio [aHR] 0.89, 95% confidence interval [CI] 0.87–0.90, p < 0.0001), difference most pronounced HFrEF (aHR 0.87, CI 0.85–0.89; [sex*HF subtype] = 0.04). Females higher 1.06, 1.04–1.08, HFpEF 1.11, 1.07–1.14; 0.001). Conclusions While mortality, experienced significantly loss time than hospitalization.