Modulating the Lipase‐Mediated Bioactivity of Particle‐Lipid Conjugates Through Changes in Nanostructure and Surface Chemistry

• DOI: 10.1002/ejlt.201700213
• Publication Date: 2017-10-12T14:12:43Z
• Authors: Paul Joyce; Tahnee J. Dening; Hanna Gustafsson; Clive A. Prestidge
• Keywords: Lipid digestion; Lipid droplet

The lipase‐mediated hydrolysis of triglycerides can be controlled by confining lipid droplets within highly porous nanostructured particle matrices. Novel hybrid materials with varying bioactivities toward lipase have been developed spray drying particle‐stabilized emulsions to form organized three‐dimensional architectures. In this study, the size, nanostructure, and surface chemistry particles are tailored systematically investigate influence material characteristics on activity. This is achieved (i) process (ii) structure composition particulate colloids employed stabilize precursor emulsions. all cases, colloidal self‐assembly into conjugates during water removal facilitated enhanced activity compared submicron triglyceride emulsions, lipolysis kinetics increasing in following order: polymer‐lipid (PLH) < silica‐lipid (SLH) ≤ clay‐lipid (CLH). Lipase increased as a function interfacial area substrate hydrophilicity solid matrix support. novel insights role nanostructure mechanism action harnessed for intelligent design new improved lipid‐based drug delivery vehicles functional foods. Practical Applications : Understanding controlling interaction between molecules pancreatic fundamental importance rational foods formulations. Lipid digestion body facilitates fat encapsulated bioactive compounds from gastrointestinal tract (GIT) blood surrounding tissues. Hence, bioavailability poorly soluble engineering systems that regulate three solid‐state designed finely control catalytic lipase, therefore, demonstrate high commercial potential pharmaceutical biotechnology industries. designing particle‐lipid unique nanostructures chemistries. prepared spray‐drying droplets, which induced forced agglomeration micron‐sized distinctive ability modulate through presented digestive enzyme action,