Skin derived branched‐chain fatty acids in fetal horse gut

• DOI: 10.1002/ejlt.202400060
• Publication Date: 2024-08-28T06:45:14Z
• Authors: Dong Hao Wang; Lerong Qi; Tingxiang Yang; Yachen Ren; Zhen Wang
• Keywords: 0301 basic medicine; 0303 health sciences

Abstract Branched‐chain fatty acids (BCFAs) are mostly saturated with a methyl branch at the penultimate or antepenultimate position to CH 3 end. Very‐long‐chain BCFAs (C ≥ 20) uniquely found in surface lipids. Human and California sea lion ( Zalophus californianus ) only two species that possess vernix birth, particles carry loads of BCFA gut, potentially influencing establishment first microbiota. Horse Equus caballus contains high levels its lipids, current study aims investigate if components neonatal foal's gut. Electron ionization tandem mass spectrometry was used distinguish iso ‐ anteiso ‐form from straight‐chain acids. Abundant very‐long‐chain ‐BCFA, mainly even‐numbered ‐20:0, ‐22:0, ‐24:0, ‐26:0 were horse meconium but not their manure collected few months later. There little differences types concentrations between foal adult manure. Moderate ‐BCFA also found. Comparisons skin cholesterol ester content human suggest derived origin. The expands our knowledge on gut nutritional environment newborn horse, further is needed establish relationship microbiota composition hours life. Practical Applications : (BCFA) bioactive compounds caseosa, lipid‐laden material covering baby. reaches third trimester gestation until birth. However, exact functionality mechanisms fetus remain unclear. clarify lipid conditions foals identify associations critical point when horse's establishes itself. findings lay path for studying physiological functions models, accelerating research related BCFA.