Glucose as an Eco‐Friendly Reductant in a One‐Pot Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones

• DOI: 10.1002/ejoc.202000970
• Publication Date: 2020-08-10T23:26:01Z
• Authors: Thiago dos Santos; Caroline Grundke; Tobias Lucas; Luca Großmann; Giuliano Cesar Cl...; Till Opatz
• Keywords: Environmentally Friendly; Aqueous medium

Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes a source of carbon and/or hydrogen to yield products high economical and biological impact. Herein, we report versatile environmentally friendly protocol for the one‐pot synthesis 2,3‐dihydroquinazolin‐4(1 H )‐ones, privileged scaffold medicinal chemistry, based on use eco‐friendly reductant alkaline aqueous medium. This method viewed blueprint development further sequences involving reductant.