Visible‐Light‐Induced Metal‐Free Three‐Component Amidoheteroarylation of Alkenes to Synthesize β‐(Hetero)arylethylamines

• DOI: 10.1002/ejoc.202400185
• Publication Date: 2024-03-21T15:09:21Z
• Authors: Qiange Feng; He Wang; Yang Liu; Lin Wei; Jing Sun; Xin Wang; Ran Sun; Yujia Wang; Lei Li
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractHerein, visible‐light‐induced metal‐free three‐component amidoheteroarylation of alkenes with quinoxalin‐2(1H)‐ones and N‐sulfonylaminopyridinium salts is developed. This protocol involves a radical relay process in which the N‐centered radicals undergo chemoselective addition to alkenes to form an alkyl radical that selectively combines with heteroarenes, leading to the formation of C−C and C−N bonds in one step under mild reaction conditions. The involved high efficiency and selectivity, wide substrate scope, and excellent functional‐group compatibility demonstrate the practicability of the developed protocol.