Smartphone‐based colorimetric chiral recognition of ibuprofen using aptamers‐capped gold nanoparticles

• DOI: 10.1002/elps.201700372
• Publication Date: 2017-11-29T17:57:33Z
• Authors: Jing Ping; Zhenjiang He; Jianshe Liu; Xuehui Xie
• Keywords: Aptamer; Ibuprofen

Sensitive and fast detection of ibuprofen enantiomers is very critical for required routine monitoring risk assessment trace pollutants in water samples. Here a simple, rapid highly sensitive android smartphone application chiral recognition was developed. Aptamer-capped gold nanoparticles (AuNPs) demonstrated as an efficient platform (S)-(+)-ibuprofen (S-Ibu) (R)-(-)-ibuprofen (R-Ibu). Detachment enantioselective aptamer from the AuNPs surface binding with enantiomer Ibu lead to aggregation, which allows enantiodiscrimination by absorbance changes solution UV-vis spectrum. Under optimal conditions, limit S-Ibu R-Ibu 1.24 3.91 pg/mL, respectively. These probes showed good ability mixed samples (i.e. + R-Ibu) environmental advantages can be further developed quantitative measurement smartphone, opens new opportunities on-site simple practical manner.