Determination of antidepressants in human urine extracted by magnetic multiwalled carbon nanotube poly(styrene‐co‐divinylbenzene) composites and separation by capillary electrophoresis

• DOI: 10.1002/elps.201700496
• Publication Date: 2018-04-20T15:02:26Z
• Authors: Khaled Murtada; Fernando de Andrés; Angel Ríos; Mohammed Zougagh
• Keywords: Divinylbenzene; Solid phase extraction

Abstract Poly(styrene‐co‐divinylbenzene)‐coated magnetic multiwalled carbon nanotube composite synthesized by in‐situ high temperature combination and precipitation polymerization of styrene‐co‐divinylbenzene has been employed as a sorbent for the solid phase extraction antidepressants in human urine samples. Fluoxetine, venlafaxine, citalopram sertraline were, afterwards, separated determined capillary electrophoresis with diode array detection. The presence nanotubes native poly(styrene‐co‐divinylbenzene) not only simplified sample treatment but also enhanced adsorption efficiencies, obtaining recoveries higher than 89.5% all analytes. Moreover, this can be re‐used at least ten times without loss efficiency limits detection ranging from 0.014 to 0.041 μg/mL were calculated. Additionally, precision values 0.08 7.50% 0.21 3.05% obtained responses migration analytes, respectively.