Distinguishing three distinct biogeographic regions with an in‐house developed 39‐AIM‐InDel panel and further admixture proportion estimation for Uyghurs

• DOI: 10.1002/elps.201800448
• Publication Date: 2019-02-13T14:01:26Z
• Authors: Qiong Lan; Chunmei Shen; Xiaoye Jin; Yuxin Guo; Tong Xie; Chong Chen; Wei Cui; Yating Fang; Guang Yang; Bofeng Zhu
• Keywords: Indel

In the forensic field, ancestry-informative markers (AIMs) showing remarkable allele frequency discrepancies can be useful in deducing likely ancestral origin of a person or estimating ancestry component proportions an admixed population individual. Diallelic single nucleotide polymorphisms are genetic commonly used for inference, but genotyping methods fail to fulfil demands cost-effectiveness and simplicity experimental manipulation. To overcome limitations, 39 insertion/deletion polymorphism multiplex panel was developed present study perform assignment individuals from three distinct biogeographic regions (Africa, Europe, East Asia). And design, we also attempted incorporate AIM-insertion/deletion exhibiting allelic differences Han, Uyghur, Tibetan populations into assay, further expecting provide valuable information refining inference within Chinese populations. Statistical analyses were performed estimate efficiency this clustering continents mentioned above their corresponding populations, which indicated potential inference. Besides, estimated Uyghur group STRUCTURE analysis revealed that Uyghurs Urumchi city northern Xinjiang exhibited distinctly pattern Asian European components with ratio 49:44, reflecting relatively higher contribution gene pool group.