Development of a microchip capillary electrophoresis method for determination of the purity and integrity of mRNA in lipid nanoparticle vaccines

Electrophoresis, Microchip Vaccines 0303 health sciences 03 medical and health sciences Liposomes Electrophoresis, Capillary Nanoparticles RNA, Messenger 3. Good health
DOI: 10.1002/elps.202100272 Publication Date: 2021-11-22T09:56:15Z
ABSTRACT
Messenger RNA (mRNA)-based vaccines are advantageous because they can be relatively quicker and more cost efficient to manufacture compared other traditional vaccine products. Lipid nanoparticles have three common purposes: delivery, self-adjuvanting properties, mRNA protection. Faster development requires an fast assay monitor purity integrity. Microchip CE is known a robust technology that capable of rapid separation. Here, we describe the optimization integrity for mRNA-based encapsulated in lipid using commercial microchip-based The analytical parameters optimized were assessed method stability indicating assay.
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