Analysis of spatio‐temporal propagation of occipito‐frontal spikes in childhood epilepsies by 3D sequential voltage mapping and dipole localization

• DOI: 10.1002/epd2.20009
• Publication Date: 2023-03-13T07:20:23Z
• Authors: Neetha Balaram; James Jose; Abdul V. Gafoor; Smita Balachandran; Joe James; Aparna Ramachandran; Shivakumar H Ramesh; Anjana Prabhakaran
• Keywords: Frontal lobe; Occipital lobe

We sought to study the spatio-temporal propagation of occipito-frontal spikes in childhood epilepsies by voltage mapping and dipole localization identify types based on onset, propagation, stability their dipoles.Sleep EEG data children, aged 1-14 years, with a minimum 1 h recording from June 2018 2021, were analyzed spikes. In total, 150 successive manually selected each using source software averaged automated pattern matching threshold 80%, sequential 3D maps spike analyzed. Stability quotient (SQ) was calculated as total number averages/150. Stable defined SQ ≥ .8. Dipole analysis performed principal component an age-appropriate template head model.Ten children identified; five self-limited epilepsy autonomic seizures (SeLEAS) non-SeLEAS epilepsies. Three identified: (1) narrow stable dipoles seen all SeLEAS which "apparently" synchronous bilateral clone-like interval 10-30 ms homogeneous unilateral medial parieto-occipital region ipsilateral mesial frontal region; (2) wide one child developmental and/or epileptic encephalopathy spike-wave activation sleep (D/EE-SWAS) 45 ms, caused focal deeper temporal focus peri-rolandic cortex; (3) unstable four lesional latency >50 heterogeneous patterns poor intra-individual stability.We successfully identified different Although term "occipito-frontal" is used describe these 10-20 system, true occipital regions not necessary. It possible differentiate idiopathic symptomatic cases analyzing