A dynamic covalent polymeric antimicrobial for conquering drug‐resistant bacterial infection

• DOI: 10.1002/exp.20210145
• Publication Date: 2022-05-23T09:21:09Z
• Authors: Fan Huang; Xiaoyao Cai; Xiaoxue Hou; Yumin Zhang; Jinjian Liu; Lijun Yang; Yong Liu; Jianfeng Liu
• Keywords: Nanocarriers

Increasing bacterial drug resistance to antibiotics has posed a major threat contemporary public health, which resulted in large number of people suffering from serious infections and ending up dying without any effective therapies every year. Here, dynamic covalent polymeric antimicrobial, based on phenylboronic acid (PBA)-installed micellar nanocarriers incorporating clinical vancomycin curcumin, is developed overcome drug-resistant infections. The formation this antimicrobial facilitated by reversible interactions between PBA moieties micelles diols vancomycin, impart favorable stability blood circulation excellent acid-responsiveness the infection microenvironment. Moreover, structurally similar aromatic curcumin molecules can afford π-π stacking interaction realize simultaneous delivery release payloads. In comparison with monotherapy, demonstrated more significant eradication bacteria vitro vivo due synergism two drugs. Furthermore, achieved combination therapy shows satisfied biocompatibility unwanted toxicity. Considering various contain diol structures, simple robust strategy become universal platform combat ever-threatening infectious diseases.