Plasma signature metabolites of dietary fat intake characterize associations with prevalent metabolic syndrome

• DOI: 10.1002/fft2.505
• Publication Date: 2024-10-17T05:25:40Z
• Authors: Xuzhi Wan; Hongbo Shi; Wei Jia; Li Zhu; Yimei Tian; Denghui Meng; Anli Wang; Yaoran Li; Xiaohui Liu; Haoyu Li; Lange Zhang; Pan Zhuang; Yu Zhang; Jingjing Jiao
• Keywords: plasma metabolomics; Nutrition. Foods and food supply; n − 3 polyunsaturated fatty acids; TX341-641; dietary fats; TP368-456; signature metabolites; metabolic syndrome; Food processing and manufacture

Abstract The metabolic response to dietary fat intake and its relation with syndrome (MetS) remains unclear. Here, we identified related signature metabolites characterized their associations MetS prevalence. We enrolled 236 participants from the Precision Nutrition Food Safety for Dietary Prevention of Chronic Disease study in China. Nontargeted metabolomics was conducted investigate plasma metabolome. were assessed using elastic net regression a 10‐fold cross‐validation. multi‐metabolite profiles comprising 28, 19, 23, 31, 25 metabolites, which robustly correlated saturated fatty acids, monounsaturated polyunsaturated acids (PUFAs), n − 3 PUFAs, 6 respectively ( r = .47–.54; p < .001). After adjustment potential risk factors, signatures PUFAs inversely associated 31% 48% lower prevalence, respectively. ameliorates key involved glyoxylate dicarboxylate metabolism, arginine biosynthesis, tricarboxylic acid cycle. Our findings revealed characterizing supported beneficial role especially prevention.