Genetic imbalances in 26 cases of penile squamous cell carcinoma

• DOI: 10.1002/gcc.1117
• Publication Date: 2004-11-14T11:40:10Z
• Authors: Gilda Alves; Anita Heller; Wolfgang Fiedler; Mércia Mendes Campos; Uwe Claussen; Antônio Augusto O...; Thomas Liehr
• Keywords: Adult; Aged, 80 and over; Male; Gene Amplification; Gene Dosage; Nucleic Acid Hybridization; Middle Aged; 03 medical and health sciences; 0302 clinical medicine; Carcinoma, Squamous Cell; Humans; Chromosome Deletion; Penile Neoplasms; Aged

AbstractTo obtain more information on chromosomal changes in the up‐to‐now poorly studied tumor class of penile squamous cell carcinoma (SCC), we performed a comparative genomic hybridization study of 26 cases of this rare tumor. DNA sequence copy number alterations (CNAs) very similar to those detected in other SCC types, such as oral and esophageal SCC, were noted. The most common copy number gains were found in 8q24, 16p11–12, 20q11–13, 22q, 19q13, and 5p15, and the most common deletions were detected in 13q21–22, 4q21–32, and along the X chromosome. Classifying the patients according to the number of CNAs showed a possible correlation with clinical outcome. © 2001 Wiley‐Liss, Inc.