Reciprocal translocations in myelodysplastic syndromes and chronic myelomonocytic leukemias: Review of 5,654 patients with an evaluable karyotype

• DOI: 10.1002/gcc.22071
• Publication Date: 2013-05-19T11:12:49Z
• Authors: Dolors Costa; Concha Muñoz; Ana Carrió; Meritxell Nomdedeu; Xavier Calvo; Francesc Solé; Elisa Luño; José Cervera; Teresa Vallespí; Daniela Berneaga; Cándida Gómez; Amparo Arias; Esperanza Such; Guillermo Sanz; Javier Grau; Andrés Insunza; María J. Calasanz; María T. Ardañaz; Jesús M. Hernández; Gemma Azaceta; Sara Álvarez; Joaquín Sánchez; María L. Martín; Joan Bargay; Valle Gómez; Carlos Javier Cer...; María J. Allegue; Rosa Collado; Elias Campo; Benet Nomdedeu
• Keywords: Chronic myelomonocytic leukemia; Abnormality; Chromosomal Abnormality

The infrequency of translocations in myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemias (CMML) makes their identification reporting interesting for the recognition recurrent ones genes involved these neoplasias. aims this study were to identify new associated with MDS CMML establish frequency a cohort 8,016 patients from Spanish Group database. karyotype was evaluable 5,654 (70%) patients. Among those, 2,014 (36%) had chromosomal abnormalities, including 213 (10%) identified 195 balanced 183 (86%) cases unbalanced 30 (14%) cases. All chromosomes found be translocations, single exception Y chromosome. most frequently decreasing frequency: 3, 1, 7, 2, 11, 5, 12, 6, 17. Translocations karyotypes as unique abnormality (33%), another (11%), part complex (17%), monosomal (38%). There 155 not previously described or nine them appeared recurrent.