18F‐FDG‐PET/CT versus panendoscopy for the detection of synchronous second primary tumors in patients with head and neck squamous cell carcinoma

• DOI: 10.1002/hed.21184
• Publication Date: 2009-07-22T15:50:46Z
• Authors: Stephan K. Haerle; Klaus Strobel; Thomas F. Hany; Daniel Sidler; Sandro J. Stoeckli
• Keywords: PET-CT

Abstract Background. This study assesses the additional value of 18 F‐fluoro‐2‐deoxy‐ D ‐glucose positron emission tomography/CT ( F‐FDG‐PET/CT) with respect to synchronous primaries in patients undergoing panendoscopy for staging head and neck squamous cell carcinoma. Methods. In all, 311 underwent both modalities. Cytology, histology, and/or clinical/imaging follow‐up served as reference standard. Results. The prevalence second primary tumors detected by was 4.5%, compared 6.1% F‐FDG‐PET/CT. sensitivity 74%, specificity 99.7%, positive predictive (PPV) 93%, negative (NPV) 98%. F‐FDG‐PET/CT 100%, 95.7%, PPV 59%, NPV 100%. Conclusions. is superior panendoscopy. With a F‐FDG‐PET/CT, extent endoscopy can be reduced area tumor. Due costs, recommended only advanced disease assess potential distant disease. early‐stage cancer, accurate enough rule out secondary tumors. © 2009 Wiley Periodicals, Inc. Head Neck, 2010