ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma

• DOI: 10.1002/hed.23003
• Publication Date: 2012-05-14T10:34:37Z
• Authors: Jane H. Zhou; Ehab Y. Hanna; Dianna Roberts; Randal S. Weber; Diana Bell
• Keywords: Adenoid Cystic Carcinoma; Perineural invasion; Tissue microarray

Abstract Background Adenoid cystic carcinoma (ACC) cells with a high level of ALDH1, known cancer stem cell (CSC) marker, had higher tumorigenic, invasive, and metastatic abilities. We examined the immunohistochemical expression ALDH1 in ACC its correlation survival. Methods Archival paraffin blocks were analyzed. A tissue microarray was constructed analyzed using anti‐ALDH1 monoclonal antibody. Correlations between clinical histological parameters assessed by chi‐square tests. Survival Kaplan–Meier method log‐rank test. Results Most tumors (63%) showed stromal staining only, 11% both epithelial expression, 26% did not show either or staining. Statistical analyses any pattern tumor histology, size, perineural invasion. There no significant differences survival among 3 patterns expression. Conclusion Other factors, besides CSCs, may play important roles tumorigenesis, differentiation, progression these tumors. © 2012 Wiley Periodicals, Inc. Head Neck, 2013