Correlation of human papillomavirus status with apparent diffusion coefficient of diffusion‐weighted MRI in head and neck squamous cell carcinomas

• DOI: 10.1002/hed.24051
• Publication Date: 2015-03-18T00:05:13Z
• Authors: Juliette P. Driessen; Alexander J. M. v...; Pauline M. W. van...; Luuk M. Janssen; Chris H. J. Terhaard; Frank A. Pameijer; Stefan M. Willems; Inge Stegeman; Wilko Grolman; Marielle E.P. Phi...
• Keywords: Male; diffusion; Papillomavirus Infections; Middle Aged; Prognosis; diffusion-weighted MRI; human papillomavirus (HPV); 6. Clean water; 3. Good health; head and neck squamous cell carcinoma (HNSCC); 03 medical and health sciences; Diffusion Magnetic Resonance Imaging; 0302 clinical medicine; Otorhinolaryngology; Head and Neck Neoplasms; Journal Article; Carcinoma, Squamous Cell; apparent diffusion coefficient; Humans; Female; 10. No inequality; Papillomaviridae; Aged; Retrospective Studies

Identification of prognostic patient characteristics in head and neck squamous cell carcinoma (HNSCC) is great importance. Human papillomavirus (HPV)-positive HNSCCs have favorable response to (chemo)radiotherapy. Apparent diffusion coefficient, derived from diffusion-weighted MRI, has also shown predict treatment response. The purpose this study was evaluate the correlation between HPV status apparent coefficient.Seventy-three patients with histologically proven HNSCC were retrospectively analyzed. Mean pretreatment coefficient calculated by delineation total tumor volume on MRI. analyzed correlated coefficient.Six HPV-positive. HPV-positive showed significantly lower compared HPV-negative. This independent other characteristics.In HNSCC, positive correlates low mean coefficient. value might be partially attributed a status. © 2015 Wiley Periodicals, Inc. Head Neck 38: E613-E618, 2016.