Neutrophil‐to‐lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma

• DOI: 10.1002/hed.24159
• Publication Date: 2015-06-04T01:27:26Z
• Authors: Saleh Rachidi; Kristin Wallace; John M. Wrangle; Terry A. Day; Anthony J. Alberg; Zihai Li
• Keywords: Male; 0301 basic medicine; Neutrophils; Middle Aged; Prognosis; Disease-Free Survival; 3. Good health; Survival Rate; 03 medical and health sciences; Head and Neck Neoplasms; Carcinoma, Squamous Cell; Humans; Female; Lymphocyte Count; Lymphocytes; Aged; Retrospective Studies

Current prognostic criteria are insufficient in predicting outcomes head and neck cancer, necessitating new, readily available biomarkers.Pretreatment neutrophil lymphocyte counts their ratio (NLR) were retrospectively investigated for correlation with overall survival while controlling demographic clinical confounders.Patients the highest tertile of those lowest lymphocytes experienced shorter than rest population. Patients NLR at a higher risk compared after multivariate analysis (hazard [HR] = 2.39; p .0001). Additionally, was lower patients human papillomavirus (HPV)-positive tumors to HPV-negative predicted both tumor types.Neutrophil strong biomarkers opposing significance is robust predictor oral, pharyngeal, laryngeal squamous cell carcinomas. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1068-E1074, 2016.