Preoperative low skeletal muscle mass as a risk factor for pharyngocutaneous fistula and decreased overall survival in patients undergoing total laryngectomy

• DOI: 10.1002/hed.25638
• Publication Date: 2019-01-21T04:35:04Z
• Authors: Sandra I. Bril; Thomas F. Pezier; Bernard M. Tijink; Luuk M. Janssen; Weibel W. Braunius; Remco de Bree
• Keywords: Male; Cutaneous Fistula; Laryngectomy; survival; Body Mass Index; sarcopenia; surgery; 03 medical and health sciences; head and neck neoplasms; Postoperative Complications; 0302 clinical medicine; Risk Factors; postoperative complications; computer-assisted image analysis; Humans; Muscle, Skeletal; Laryngeal Neoplasms; Aged; Neoplasm Staging; Retrospective Studies; body composition; skeletal muscle mass; Original Articles; Pharyngeal Diseases; Length of Stay; Middle Aged; 3. Good health; Survival Rate; Otorhinolaryngology; Female

Low skeletal muscle mass (SMM) is associated with postoperative complications, prolonged hospital stay, and short overall survival (OS) in surgical oncology. We aimed to investigate this association patients undergoing total laryngectomy (TL).A retrospective study was performed of TL. SMM measured using CT or MRI scans at the level third cervical vertebra (C3).In all, 235 were included. observed 109 (46.4%). Patients low had more pharyngocutaneous fistulas (PCFs) than normal (34.9% vs 20.6%; P = .02) stay (median, 17 14 days; < .001). In multivariate analysis, (hazards ratio, 1.849; 95% confidence interval, 1.202-2.843) high N stage significant prognosticators decreased OS.Low PCF an independent prognostic factor for shorter OS.