A matched pair analysis of oncological outcomes in human papillomavirus‐negative oropharyngeal squamous cell carcinoma: Transoral surgery versus radiotherapy or concurrent chemoradiation

• DOI: 10.1002/hed.26771
• Publication Date: 2021-05-29T13:08:59Z
• Authors: Alok Thakar; Smriti Panda; Aanchal Kakkar; Vishwajeet Singh; Chirom Amit Singh; Atul Sharma; Suman Bhasker; Padmavathi Krishn...; Suresh C. Sharma
• Keywords: Chemoradiotherapy; Subgroup analysis

Abstract Background With the termination of RTOG 1221, there remains a lacuna regarding optimal treatment for human papillomavirus (HPV)‐negative oropharyngeal squamous cell carcinoma (OPSCC). Methods Matched pair analysis with propensity score matching (PSM) between Arm I (transoral surgery [TOS] + risk‐stratified adjuvant treatment) and II (nonsurgical − radiation/chemoradiation) in HPV(−) OPSCC. Results Unmatched comparison ( n = 57) 89) indicated significantly better overall survival (OS) disease‐free (DFS) I. PSM by matched pairs 48, 24 each arm) 5‐year OS at 80% 72.1%, respectively, p > 0.05) corresponding DFS 65.3% 33.4% 0.05). Subgroup did not demonstrate statistical difference outcomes stage III, but IV tumors had than (4‐year OS: 100% vs. 21%, 0.04; DFS: 75% 14.3%, 0.04). Conclusions TOS +/− was found to have oncological par nonsurgical modalities I–III OPSCC, whereas distinct advantage noted case tumors.