“Fact or fiction?”: Oral cavity cancer innonsmoking,nonalcoholdrinking patients as a distinct entity—Scoping review

• DOI: 10.1002/hed.26824
• Publication Date: 2021-07-27T10:28:53Z
• Authors: John Adeoye; Jia Yan Tan; Cheuk Man Ip; Siu‐Wai Choi; Peter Thomson
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Alcohol Drinking; Risk Factors; Smoking; 610; Humans; Mouth Neoplasms; Areca; 3. Good health

Abstract Oral cavity cancer is often described as a lifestyle‐related malignancy due to its strong associations with habitual factors, including tobacco use, heavy alcohol consumption, and betel nut chewing. However, patients no genetically predisposing conditions who do not indulge in these risk habits are still being encountered, albeit less commonly. The aim of this review summarize contemporaneous reports on nonsmoking, nonalcohol drinking (NSND) patients. We performed database searching identify relevant studies from January 1, 2000 March 31, 2021. Twenty‐six articles 20 were included study. found that individuals mostly females their eighth decade tumors involving the tongue gingivobuccal mucosa. This also observed likely diagnosed early stage overexpression programmed death‐ligand 1 (PD‐L1) increased intensity tumor infiltrating lymphocytes. Treatment response disease‐specific prognosis largely comparable between NSND smoking/drinking