A comparison of timing and patterns of treatment failure, and survival outcomes after progression between HPV+ and HPV− patients undergoing chemoradiation for oropharyngeal squamous cell carcinomas

• DOI: 10.1002/hed.27600
• Publication Date: 2023-12-15T18:39:21Z
• Authors: Francisco Laxague; Peter Y. F. Zeng; Dorsa Zabihi; Naif Fnais; Mohammed Alshahrani; Kevin Fung; Danielle MacNeil; Adrian Mendez; John Yoo; Joseph S. Mymryk; John W. Barrett; David A. Palma; Anthony C. Nichols
• Keywords: Univariate analysis

Abstract Background We aimed to analyze and compare the timing patterns of treatment failure, survival after progression between HPV‐positive (HPV+) HPV‐negative (HPV−) patients undergoing chemoradiation for oropharyngeal squamous cell carcinomas (OPSCC). Methods A retrospective review was performed all primary OPSCC 2008 2021. Demographic clinical data were collected. Kaplan–Meier estimates overall (OS), time recurrence/metastases (TTR) compared using log‐rank test, with Cox regression used multivariable modeling comparing HPV+ HPV− patients. Results developed recurrence or metastases at earlier points than (8.8 vs. 15.2 months, p < 0.05), due local/locoregional distant metastases, but not isolated regional recurrences. exclusively occurred in a single organ, most commonly lungs bone, while frequently had multi‐organ involvement wide variety locations ( 0.05). Once (recurrence/metastases) diagnosed, experienced superior on univariate multivariate analysis, largely improved outcomes recurrences There no differences metastases. Conclusion relapse later sites. experience recurrence, which does hold true These can be useful inform prognosis guide decisions recurrent OPSCC.