Assessing survival outcomes of patients with oral tongue squamous cell carcinoma: Focus on age, sex, and stage

• DOI: 10.1002/hed.27786
• Publication Date: 2024-05-02T11:49:11Z
• Authors: Saagar Pamulapati; Marin Abousaud; Yixuan Li; Asari Ekpenyong; Soumon Rudra; Jill S. Remick; James E. Bates; William A. Stokes; Mark W. McDonald; Nicole C. Schmitt; Mark W. El‐Deiry; Mihir R. Patel; Conor E. Steuer; Jeffrey M. Switch...; Dong M. Shin; Yong Teng; Anthea Hammond; Nabil F. Saba
• Keywords: Male; Adult; Aged, 80 and over; Age Factors; Kaplan-Meier Estimate; Middle Aged; Prognosis; United States; Tongue Neoplasms; Survival Rate; Cohort Studies; 03 medical and health sciences; Sex Factors; 0302 clinical medicine; Carcinoma, Squamous Cell; Humans; Female; Registries; Retrospective Studies; Aged; Neoplasm Staging

AbstractBackgroundThe purpose of this study was to provide further insights into whether age and/or sex are associated with prognosis in oral tongue squamous cell carcinoma.MethodsThis was a retrospective cohort study utilizing hospital registry data from 2006 to 2016 obtained from the National Cancer Database. Identified patients were divided into various cohorts based on age, sex, and staging. A descriptive analysis was performed using chi‐square tests and overall survival rates were estimated using Kaplan–Meier method.ResultsA total of 17 642 patients were included in the study. The 5‐year overall survival rates were 82.0% (95% CI: 79.8%–84.0%) in younger patients versus 67.5% (95% CI: 66.7%–68.3%, p‐value <0.0001) older patients. The median overall survival for females was 143.4 months (95% CI: 133.2–NA) versus 129.8 (95% CI: 125.4–138.7, p‐value <0.0001) in males.ConclusionsOur analysis suggests that younger age and female sex are both predictors of improved survival in oral tongue squamous cell carcinoma.