Morbidity of multimodal treatments including endoscopic surgery for sinonasal malignancies: Results of an international collaborative study on 940 patients (MUSES)

• DOI: 10.1002/hed.27916
• Publication Date: 2024-08-22T02:47:50Z
• Authors: Giacomo Bertazzoni; Alessandro Vincig...; Domitille Camous; Marco Ferrari; Davide Mattavelli; Mario Turri‐Zanoni; Alberto Schreiber; Stefano Taboni; Vittorio Rampinelli; Alberto Daniele A...; Benjamin Verillaud; Cesare Piazza; Paolo Battaglia; Maurizio Bignami; Alberto Deganello; Paolo Castelnuovo; Piero Nicolai; Philippe Herman
• Keywords: Surgical resection; Multimodal therapy

Abstract Introduction In the management of sinonasal malignancies treatment‐induced morbidity and mortality is gaining relevance both for surgical approaches (endoscopic open resection) non‐surgical therapies. The aim this multicenter study to assess complications associated with endoscopic surgery treatments (neoadjuvant and/or adjuvant) malignant tumors. Methods All patients nasoethmoidal treated curative intent or endoscopic‐assisted at three referral centers uniform policies were included. Neo‐ adjuvant (chemo)radiotherapy was administered according histology pathological report. Demographics, treatment characteristics, related retrieved. data analyzed univariate multivariate statistics independent predictors complications. Results Nine hundred forty included, 643 males (68%) 297 females (32%). A total 225 identified in 187 (19.9%): cerebrospinal fluid (CSF) leak (3.5%), mucocele (2.3%), site bleeding (2.0%), epiphora radionecrosis (2.0%) most common. Treatment‐related 0.4%. Variables independently analysis principally dural resection (OR 1.92), cranioendoscopic multiportal 2.93), repair multilayer technique less than layers 2.17), graft different from iliotibial tract 3.29). Conclusion Our shows that modern radiotherapy are limited treatment‐related mortality. CSF radionecrosis, although rare, remain frequent should be further addressed by future research efforts.