Oncogenic Human Papillomaviruses Drive One‐Third of Sinonasal Squamous Cell Carcinoma and Are Not Mutually Exclusive for Gene Mutations

• DOI: 10.1002/hed.28084
• Publication Date: 2025-01-25T09:48:52Z
• Authors: Maxime Henrion; Valérie Costes‐Ma...; Ignacio González ...; Nathalie Boulle; Jérôme Solassol; Julie Vendrell; Renaud Garrel; Aude Trinquet; Vanessa Lacheretz...

ABSTRACT Background The detection rate of oncogenic human papillomaviruses (HPVs) in sinonasal squamous cell carcinomas (SNSCCs) varies among studies. mutational landscape SNSCCs remains poorly investigated. Methods We investigated the prevalence and prognostic significance HPV infections based on p16 protein expression, HPV‐DNA detection, E6/E7 mRNA expression using immunohistochemistry, polymerase chain reaction, situ hybridization, respectively. In addition, we evaluated genetic mutations 59 patients next‐generation sequencing. Results One‐third were truly HPV‐driven tumors associated with a nonkeratinizing morphology ( p = 0.01) did not correlate prognosis. following gene detected: TP53 , PIK3CA CDKN2A EGFR FGFR3 . These occurred alone, association with, or HPV. Conclusion high‐risk driven lesions. However, HR‐HPV are mutually exclusive. Further studies required to analyze value these associations.