Localization of epidermal growth factor receptor in hepatocyte nuclei

• DOI: 10.1002/hep.1840130104
• Publication Date: 2007-03-03T23:41:01Z
• Authors: Ulrich Marti; Susan Jo Burwen; Alan Wells; Mary E. Barker; Sandra Huling; Anna M. Feren; Albert L. Jones
• Keywords: Liver receptor homolog-1

Experiments undertaken to investigate the binding of epidermal growth factor by hepatocyte nuclei showed that: (a) isolated from both normal and regenerating rat liver are capable 125I-epidermal factor, (b) nuclear factor-binding protein is similar in molecular weight plasma membrane receptor, (c) monoclonal antibodies produced against receptor recognize (d) has an affinity for comparable that but fewer (approximately 10%) receptors available per unit compared with membrane.