High familial prevalence of gallstones in the first-degree relatives of gallstone patients

• DOI: 10.1002/hep.1840220122
• Publication Date: 2007-03-04T04:31:43Z
• Authors: Shiv K. Sarin; Vir S. Negi; Richa Dewan; Smailaja Sasan; Anoop Saraya
• Keywords: First-degree relatives

Limited information is available on the prevalence of gallstones in first-degree relatives gallstone patients. Three groups subjects were studied by real-time ultrasound examination: group A, 105 index patients (male/female; 20:85); B, 330 patients; C, matched controls for A (n = 105) and B 330) subjects. Dietary, anthropometric, biochemical investigations carried out. In 39 (37%) cases, one or more additional family members had (positive-index case). The positive-index cases younger than remaining (mean age, 33.1 +/- 14 vs. 44.5 13.1 years; P < .05). Fifty-one (15.5%) gallstones, nearly four a half times (95% confidence interval [CI], 2.4 to 8.5) often control population (12 [3.6%]). Thirty-three 51 (65%) positive women; mother (37.3%), sister (17.6%) daughters (10%) There was no difference diet, physical activity, serum lipid profile between their controls. Our results show that there strong familial predisposition formation. Female young should be routinely screened gallstones.