HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease

• DOI: 10.1002/hep.20215
• Publication Date: 2004-05-27T20:02:03Z
• Authors: Raúl J. Andrade; Isabel M. Lucena; Anabel Alonso; Miren García-Cort'es; Elena García-Ruiz; Rafael Benitez; Carmen M. Fernández; Gloria Pelaez; Manuel Romero; Raquel Corpas; José Antonio Durán; Manuel Jiménez; Luis Rodrigo; Flor Nogueras; Rafael Martín-Viv...; José María Navarro; Javier Salmerón; Felipe Sánchez de...; Ramón Hidalgo
• Keywords: Liver disease; Genetic predisposition

Drug-induced idiosyncratic liver disease (DIILD) depends largely on host susceptibility factors. Small studies support the genetic influence of human leukocyte antigen (HLA) class II molecules predisposition to DIILD. We sought associations between HLA-DRB and -DQB alleles DIILD considered collectively or according biochemical expression damage. studied a total 140 patients with definitive probable diagnosis DIILD, as assessed Council for International Organizations Medical Sciences scale, 635 volunteer bone marrow blood donors serving controls. HLA-DRB1* -DQB1* genotyping was performed by hybridization sequence-specific oligonucleotides after genomic amplification. The group did not differ from control subjects regard distribution antigens. frequencies DRB1*15 (35.4% vs. 18.6% controls; P = .002; odds ratio [OR] 2.31) DQB1*06 (61.5% 40.8%; .001; OR 2.32) were significantly increased in cholestatic/mixed type damage comparison healthy subjects. By contrast, DRB1*07 (16.9% 35.4%; .003; 0.37) DQB1*02 (32.3% 55.8%; .0003; 0.39) decreased. In conclusion , there is no association any specific HLA allele propensity develop However, associated appears play role injury hepatotoxicity may explain why given drug cause different patterns (Hepatology 2004;39:1603-1612.)