High frequency of cholestasis in generalized pustular psoriasis: Evidence for neutrophilic involvement of the biliary tract

• DOI: 10.1002/hep.20305
• Publication Date: 2004-08-13T16:12:53Z
• Authors: Manuelle Viguier; Matthieu Allez; Anne-Marie Zagdanski; Philippe Bertheau; Eric de Kerviler; Michel Rybojad; Patrice Morel; Louis Dubertret; Marc Lémann; Hervé Bachelez
• Keywords: Generalized pustular psoriasis

Generalized pustular psoriasis is a rare form of that sometimes associated with extracutaneous manifestations. Evidence for biliary involvement has been suggested in isolated cases. We investigated the prevalence and nature liver abnormalities occurring this disease. Twenty-two patients consecutively admitted generalized who underwent biological tests at time attack during following weeks were included. Twenty (90%) had least one abnormal parameter. Eleven (50%) pronounced abnormalities: jaundice (4/22), gammaglutamyl transferase higher than 5 times normal value (10/22), alkaline phosphatase twice (7/22), and/or aminotransferases 3 (7/22). These returned to range remission psoriasis, suggesting severe could be cutaneous Neutrophilic cholangitis was observed on biopsy. Persistent magnetic resonance cholangiopancreatography features similar those sclerosing found 4 studied. No causal factor other identified. In conclusion , our results demonstrate high frequency psoriasis. Biliary related neutrophilic should added spectrum manifestations disease, physicians aware such complication. (Hepatology 2004;40:452-458.)