Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis†

• DOI: 10.1002/hep.22376
• Publication Date: 2008-04-18T17:16:30Z
• Authors: Valerio Nobili; Francesco Vizzutti; Umberto Arena; Juan G. Abraldes; Fabio Marra; Andrea Pietrobatt...; Rodolfo Fruhwirth; Matilde Marcellini; Massimo Pinzani
• Keywords: Transient elastography; Steatohepatitis; Chronic liver disease; Nonalcoholic steatohepatitis; Liver disease

Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in chronic liver patients. In this study, we assessed the value of TE for prediction fibrosis stage cohort pediatric patients with nonalcoholic steatohepatitis. Furthermore, interobserver agreement was evaluated. performed 52 consecutive biopsy-proven steatohepatitis (32 males, 20 females, age 13.6 +/- 2.44 years). The area under receiver operating characteristic curves "any" (>or=1), significant (>or=2), or advanced (>or=3) were 0.977, 0.992, and 1, respectively. Calculation multilevel likelihood ratios showed that values <5, <7, <9 kPa, suggest presence fibrosis, between 5 7 kPa predict but some degree uncertainty. 9 stages 1 2, cannot discriminate these two stages. at least are associated fibrosis. intraclass correlation coefficient absolute 0.961.TE is an accurate reproducible methodology identify subjects without which not optimal provide reliable indication stage, biopsy should be considered when clinically indicated.